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  • Writer's pictureMichael Barr

Dale Bredesen Knows:Physical Activity Really Does Support Brain Health

Updated: Apr 28

Note: While this reporting mostly focuses on aerobic and even, when and where appropriate, high-intensity interval training, known as HIIT, Dr. Bredesen and his team have always emphasized that a mix of the three-- strength training, aerobic activities (even super short sessions: 10-20 minutes, 2-3x a week of each), and stretching slash mind-body practices-- seems to produce the best results, for mood, memory/cognition and even sleep quality.


Growing up in the Netherlands, Henriette van Praag had always been active, playing sports and riding her bike to school every day. Then, in the late-1990s, while working as a staff scientist at the Salk Institute for Biological Studies in San Diego, she discovered that exercise can spur the growth of new brain cells in mature mice. After that, her approach to exercise changed.


Whether exercise can cause new neurons to grow in adult humans is still up for debate. But even if it’s not possible, physical activity is excellent  for your brain, improving mood and cognition through a variety of cellular changes.



Exercise offers short-term boosts in cognition. Studies show that immediately after a bout of physical activity, people perform better on tests of working memory and other executive functions. This may be in part because movement increases the release of neurotransmitters in the brain, most notably epinephrine and norepinephrine.


The neurotransmitters dopamine and serotonin are also released with exercise, which is thought to be a main reason people often feel so good after going for a run or a long bike ride.

The brain benefits really start to emerge, though, when we work out consistently over time.


Studies show that people who work out several times a week have higher cognitive test scores, on average, than people who are more sedentary. Other research has found that a person’s cognition tends to improve after participating in a new aerobic exercise program for several months.


Physical activity also benefits mood. People who work out regularly report having better mental health than people who are sedentary. And exercise programs can be effective at treating people’s depression, leading some psychiatrists and therapists to prescribe physical activity.


Perhaps most remarkable, exercise offers protection against neurodegenerative diseases.


“Physical activity is one of the health behaviors that’s shown to be the most beneficial for cognitive function and reducing risk of Alzheimer’s and dementia,” said Michelle Voss, an associate professor of psychological and brain sciences at the University of Iowa.



It starts with the muscles. When we work out, they release molecules that travel through the blood up to the brain. Some, like a hormone called irisin, have “neuroprotective” qualities and have been shown to be linked to the cognitive health benefits of exercise. Christiane Wrann, an associate professor of medicine at Massachusetts General Hospital and Harvard Medical School, studies irisin.


Good blood flow is essential to obtain the benefits of physical activity. And conveniently, exercise improves circulation and stimulates the growth of new blood vessels in the brain.


Once these signals are in the brain, other chemicals are released locally. The star of the show is a hormone called brain-derived neurotrophic factor, or BDNF, that is essential for neuron health and creating new connections — called synapses — between neurons. It’s like a fertilizer for brain cells to recover from damage. And also for synapses on nerve cells to connect with each other and sustain those connections.


A greater number of blood vessels and connections between neurons can actually increase the size of different brain areas. This effect is especially noticeable in older adults because it can offset the loss of brain volume that happens with age. The hippocampus, an area important for memory and mood, is particularly affected. “We know that it shrinks with age,” Dr. Roig said. “And we know that if we exercise regularly, we can prevent this decline.”


Exercise’s effect on the hippocampus may be one way it helps protect against neurocognitive decline, which is associated with significant changes to that part of the brain.


The same goes for depression; the hippocampus is smaller in people who are depressed. And more and more researchers/clinicians are beginning to see late life depressive states, even just apathy, as a kind of prelude to dementia, although perhaps not inexorably, so this is not something to ignore, put off or dismiss.



The experts emphasized that any exercise is good, and the type of activity doesn’t seem to matter, though most of the research has involved aerobic exercise. But, they added, higher-intensity ("HIIT" workouts do appear to confer a bigger benefit for the brain.


Improving overall cardiovascular fitness level appears to be key. “It’s dose-dependent,” Dr. Wrann said. “The more you can improve your cardiorespiratory fitness, the better the benefits are.” Although not something to engage in right out of the gate for most people, high-intensity interval training ("HIIT") workouts appear to confer a bigger benefit for the brain. One can start with low-intensity, work up to moderate intensity and perhaps, when appropriate graduate to the full-one HIIT.


Background reporting for this was done by Dana G. Smith.


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